胍基乙酸及代谢产物肌酸的研究进展

doi:10.11843/j.issn.0366-6964.2018.08.002

摘要/Abstract

摘要：

胍基乙酸（guanidinoacetic acid，GAA）为肌酸（creatine）的天然前体，也称胍乙酸（guanidine acetic acid），是一种白色可溶于水的氨基酸衍生物。目前，胍基乙酸作为一种饲料添加剂广泛应用于动物生产中，以提高肌肉产量和胴体品质。本文综述了胍基乙酸的生理功能，包括刺激胰岛素释放、神经调节、改变精氨酸的代谢、调节细胞氧化状态，和胍基乙酸的代谢产物肌酸的功能，包括促进骨骼肌分化和抑制脂肪细胞分化。为后续胍基乙酸相关研究提供参考。

Abstract:

Guanidinoacetic acid, a white water-soluble amino acid derivative, is a natural precursor of creatine, also known as guanidine acetic acid. At present, guanidinoacetic acid is widely used as a feed additive to increase muscle yield and improve carcass meat quality in animal production. This review summarizes the physiological functions of guanidinoacetic acid, stimulating insulin release, neuromodulation, altering the metabolic utilization of arginine and adjusting the oxidant-antioxidant status, and the function of creatine, a metabolite of guanidinoacetic acid, promoting the differentiation of skeletal muscle and inhibiting differentiation of adipocytes. Which will provide a reference for the follow-up guanidinoacetic acid related research.

中图分类号:

S816

王誉杰, 张进威, 王讯, 李明洲, 李学伟, 马继登. 胍基乙酸及代谢产物肌酸的研究进展[J]. 畜牧兽医学报, 2018, 49(8): 1577-1584.

WANG Yu-jie, ZHANG Jin-wei, WANG Xun, LI Ming-zhou, LI Xue-wei, MA Ji-deng. The Research Progress of Guanidinoacetic Acid and Creatine[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(8): 1577-1584.

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